Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infectionArticle Published on 2022-09-232022-11-16 Journal: Nature Communications [Category] SARS, 변종, [키워드] accumulation acute respiratory syndrome adaptive affected antibody B cell CD8 T cell chronic infection circulating convalescent Coronavirus-2 Donor Effect epitope Epitopes Evolution homoplasy humoral identify Immunocompromised patient immunodeficiency Impact Infection lineages lymphoma mutant Mutation mutations neutralization Patient peptide plasma-mediated Recognition reduced Region resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutations SARS-CoV-2 sequence the spike protein Vaccine design [DOI] 10.1038/s41467-022-32772-5 PMC 바로가기
Occurrence of COVID-19 personal protective equipment (PPE) litters along the eastern coast of Palawan Island, PhilippinesArticle Published on 2022-09-012023-07-10 Journal: Marine pollution bulletin [Category] COVID19(2023년), [키워드] accumulation coronavirus Face shield facemask Microplastic pandemic. [DOI] 10.1016/j.marpolbul.2022.113934 PMC 바로가기
Impact of SARS-CoV-2 RBD Mutations on the Production of a Recombinant RBD Fusion Protein in Mammalian CellsArticle Published on 2022-08-242022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] accumulation assist B.1.351 B.1.351 variant cells chaperone chaperones contribute correlated COVID-19 diagnostic diagnostics disulphide bond domain E484K E484K mutation effort Endoplasmic reticulum expressed fusion Impact interfere mammalian mammalian cells misfolding mutant Mutation PDIA2 producing Production Protein protein disulphide isomerase protein yield. protocols RBD RBD mutation RBD protein RBD-Fc fusion protein recombinant recombinant RBD protein reduced resulting SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant secretion the RBD unfolded protein response UPR upregulation Vaccine variants [DOI] 10.3390/biom12091170 PMC 바로가기
Can machines learn the mutation signatures of SARS-CoV-2 and enable viral-genotype guided predictive prognosis?기계가 SARS-CoV-2의 돌연변이 신호를 학습하고 바이러스 유전자형 유도 예측 예후를 가능하게 할 수 있습니까?Article Published on 2022-08-152022-09-11 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] accumulation added Additive age approach Can caution changes in clade cleaning Continuous driving epitope Epitopes Factor Features Genome genomes genomic data Genotype genotypic global healthcare hallmark HLA Implications Infection information Interaction life threatening machine machine learning machine-learning mutated Mutation Mutation identification mutations nucleotide Pathogens performed Predictive Predictive prognosis Prognosis representing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity Temporal Temporal benchmarking. Total variant variants Viral diseases virus [DOI] 10.1016/j.jmb.2022.167684 PMC 바로가기 [Article Type] Article
Nanoligomers Targeting Human miRNA for the Treatment of Severe COVID-19 Are Safe and Nontoxic in Mice심각한 COVID-19 치료를 위해 인간 miRNA를 표적으로 하는 나노 올리고머는 마우스에서 안전하고 독성이 없습니다Article Published on 2022-07-112022-09-11 Journal: ACS Biomaterials Science & Engineering [Category] COVID19(2023년), SARS, 치료제, [키워드] accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antisense therapy Antiviral strategies Antiviral treatment bind biodistribution biodistribution study body weight Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease Effect fatality Histopathology Host Host immune response Human human cell human cells immune immunogenicity Infection Inflammation intranasal intraperitoneal intravenous Intravenous administration kidney kidneys liver Lungs mice microRNA miRNA MOST mouse model organ organs pandemic parameters produced question response Safe Safety. SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe case severe cases spleen targeting tested Urine with infection [DOI] 10.1021/acsbiomaterials.2c00510 PMC 바로가기 [Article Type] Article
RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIaRANBP2 및 USP9x는 아데노바이러스 마이너 코트 단백질 IIIa의 핵 수입을 조절합니다Article Published on 2022-06-162022-09-11 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] accumulation acute respiratory illness acute respiratory illnesses Adenovirus Affinity purification Amino acid amino acids Analysis analysis antiviral therapeutics antiviral therapy bind binding blockade C-terminus Cell cell nuclei cells cellular competition conjunctivitis counteract COVID-19 demonstrated deregulated disparate expression Host implication indicated infected cells Infection interact Interaction interactions mass spectrometry maturation mechanism Microscopy nuclear nuclei nucleus outbreak parasites protease Protein Proteins Ranbp2 reduced regulate respiratory pathogen retention subsequent surface plasmon surface plasmon resonance transmission electron microscopy Transport USP9x Vaccine viral genome replication Viral particles Viral protein virion virion assembly virus virus-infected cell virus-infected cells wild type [DOI] 10.1371/journal.ppat.1010588 PMC 바로가기 [Article Type] Article
Emergence of SARS-CoV-2 Omicron (B.1.1.529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemicSARS-CoV-2 오미크론(B.1.1.529) 변종, 두드러진 특징, 높은 전 세계 건강 문제 및 진행중인 COVID-19 대유행 속에서 이에 대응하기 위한 전략의 출현Review Published on 2022-06-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] accumulation Alpha Analysis animals appearance approach B.1.1.529 Beta booster doses China COVID-19 pandemic Delta Delta variants Diagnosis Efficacy emergence evade Evolution explain Features Gamma generate Genome genome analysis Health humans Immune escape immune pressure Immunity immunotherapies Immunotherapy implementation Infection late less lethality long term measure multivalent vaccine mutated Mutation mutation rate Mutation rates natural infection omicron Omicron origin patients persistence pre-existing immunity prevention Prevention and control raising receiving SARS-CoV-2 SARS-CoV-2 pandemic Spike protein the spike protein Therapies vaccination Vaccine Vaccine failure Vaccines variant Variant of concern. variants virus VoC [DOI] 10.1016/j.envres.2022.112816 PMC 바로가기 [Article Type] Review
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary Pulmonary. reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
ClusTRace, a bioinformatic pipeline for analyzing clusters in virus phylogenies바이러스 계통발생의 클러스터를 분석하기 위한 생물정보학 파이프라인인 ClusTRaceArticle Published on 2022-05-282022-09-11 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accumulation aligning Analysis bioinformatic analysis clade clades Cluster cluster analysis complex coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 transmission cut down Early detection effective effort etiologic agent feature growth in-depth analysis Lineage marker mutations offer outlier Phylogenetic analysis Phylogenetic tree phylogenies Phylogeny provide public health raising Reporting SARS-CoV-2 sequence significantly super-spreading event super-spreading events Treatment treatment of COVID-19 variant Variant calling variants of SARS-CoV-2 virus virus. Visualization [DOI] 10.1186/s12859-022-04709-8 PMC 바로가기 [Article Type] Article
Ultrastructural examination of lung “cryobiopsies” from a series of fatal COVID-19 cases hardly revealed infected cells일련의 치명적인 COVID-19 사례에서 폐 "냉동생검"의 미세구조 검사는 감염된 세포를 거의 드러내지 않음Article Published on 2022-05-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulation aggregates alveolar alveolar damage alveolar epithelium Analysis Autopsy caused Cell cell types cells coronavirus COVID-19 patient COVID-19 patients death Detachment diffuse Diffuse alveolar damage electron electron microscopy Endothelium erythrocytes Extracellular fatal COVID-19 FIBRIN fixation fixed granulocyte Histopathology hyaline membrane hyaline membranes hyperplasia immune impairment IMPROVE infected cell investigated latency leukocyte leukocytes lung lung damage macrophages mechanisms Microscopy neutrophilic Particle Patient Region Replication respiratory distress Respiratory distress syndrome Sample SARS‐CoV‐2 Stage Stress stress response the disease the patient these cell These cells Thin section thrombocyte Thrombocytes tissue Ultrastructural analysis ventilated patient ventilated patients virus Virus particle. [DOI] 10.1007/s00428-022-03308-5 PMC 바로가기 [Article Type] Article